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Enzyme ‘switch’ clue to infertility and miscarriage

first_img Share Share 12 Views   no discussions Tweet The findings could help some couples trying to have a babyScientists have identified a “fertility switch” protein which appears to increase infertility if levels are too high and fuel miscarriage if too low.An Imperial College London team took samples from the womb lining of more than 100 women.Writing in Nature Medicine they said women with unexplained infertility had high levels of the enzyme SGK1, while those who miscarried had low levels.One fertility expert said the research offered new avenues for research.About one in six women have difficulty getting pregnant, and one in 100 women trying to conceive experience recurrent miscarriages, defined as the loss of three or more consecutive pregnancies.The Imperial team also carried out mouse studies which found levels of SGK1 in the womb lining decline during the window of time during which they can fall pregnant.When extra copies of the SGK1 gene were implanted into the womb lining, these mice were unable to get pregnant.The researchers say this suggests a fall in SGK1 levels is essential for making the uterus receptive to embryos.However, if low levels of SGK1 persist into pregnancy, this appears to cause different problems.When the researchers blocked the SGK1 gene, mice had no problem getting pregnant but they had smaller litters and showed signs of bleeding, suggesting a lack of SGK1 made miscarriage more likely. ‘Focus for research’Prof Jan Brosens, who led the research at Imperial’s Institute of Reproductive and Developmental Biology, said: “Our experiments on mice suggest that a temporary loss of SGK1 during the fertile window is essential for pregnancy, but human tissue samples show that they remain high in some women who have trouble getting pregnant.“I can envisage that in the future, we might treat the womb lining by flushing it with drugs that block SGK1 before women undergo IVF.”After an embryo is implanted, the lining of the uterus develops into a specialised structure called the decidua.The team say lab tests show low levels of the enzyme may impair the ability of cells in the decidua to protect themselves against oxidative stress, a condition in which there is an excess of reactive chemicals inside cells.Dr Madhuri Salker, who also worked on the study, said: “We found that low levels of SGK1 make the womb lining vulnerable to cellular stress, which might explain why low SGK1 was more common in women who have had recurrent miscarriage.“In the future, we might take biopsies of the womb lining to identify abnormalities that might give them a higher risk of pregnancy complications, so that we can start treating them before they get pregnant.”Prof Richard Fleming, of the Glasgow Centre for Reproductive Medicine, said the research was “encouraging”.“To have something as clear as this, with a specific enzyme, is great. It is giving us something to focus on.”But, Prof Fleming, who is also a member of the British Fertility Society, warned it would be some time before the discovery translated into day-to-day practice.“It’s all very well to measure something that is missing – whether or not you can correct it is the next step.“But at least we know somewhere that’s directly involved, and can explore that.BBC Newscenter_img Share Sharing is caring! HealthLifestyle Enzyme ‘switch’ clue to infertility and miscarriage by: – October 17, 2011last_img read more

Lady Trojans Netters Winners At Home Opener

first_imgEC Volleyball defeated Rushville at all three levels tonight in our home opener.  Varsity won with the scores of 25-11, 25-10, and 25-12.East Central Varsity VB vs Rushville (8-25-15)‘We played well overall. We still have to work on eliminating our mental mistakes, but they are getting better. We served aggressively which led to a few more missed serves than what we like to see, but the girls are pushing themselves, and that is what I like to see.’ Trojans Coach Cassie Laker.Varsity is now 5-1 on the season (3-0 in EIAC).  Next up we travel to Batesville on Thursday at 5pm.last_img

Donald L. Konkler Sr.

first_imgDonald L. Konkler, Sr., 80, Batesville, died Monday, September 11, 2017, at The Waters of Batesville.  Born February 18, 1937, in Lancaster, OH, he was the son of DeWayne and Nola (Cordle) Frances.Don met Miss Shirley K. Hershberger in California while he was in the Marine Corps.  Donald worked for over 40 years at Timken Roller Bearing Company in Columbus, OH.  He was most proud that he never missed a day.  After Don retired they moved from Ohio to Batesville, IN in 2000.  Faith and family were the most important parts of Don’s life.  He and Shirley were baptized March 1973 in Somerset, OH.  A few of Don’s favorite interest were cheering on the Cincinnati Reds, fishing and gardening.  He also loved to travel and some of his favorite places were Hawaii and Florida.Don is survived by his children, Donald L. Konkler, Jr., Lancaster, OH and daughter Vicky (Bill) Wilson, Batesville, IN;  grandchildren Matthew (Melissa) Konkler, Lancaster, OH; Ashley Wilson, Baytown, TX; Lindsey Wilson, Niles, MI and brother William (Bea) Konkler, Red Bluff, CA.In addition to his parents, he was also preceded in death by his daughter, Helen and his beloved wife of 53 years Shirley K. Konkler.The family requests memorials to be made to the Ripley County Community Foundation.  There will be a private memorial service at the convenience of the family.   Meyers Funeral Home is handling arrangements.  Online condolences www.meyersfuneralhomes.comlast_img read more

Hull boss Allam set to speak out

first_img Reports of a significant change at the head of the club have surfaced this week, ranging from rumours of an outright sale to suggestions that the 75-year-old Egyptian is preparing to hand over the chairmanship to son Ehab, who has been acting chief executive since December. Allam will now address the media at 2pm on Thursday, making a statement “referencing the future of Hull City Tigers”. Hull owner Assem Allam will address growing speculation over his future at a press conference on Thursday. The very wording of that sentence, in a short press release distributed by the club on Tuesday, suggests Allam is in combative mood. Allam saved the club from financial disaster when he bought it in 2010 but incurred the wrath of many supporters on last season’s return to the Barclays Premier League with his ill-fated plan to change the official name from Hull City AFC to Hull Tigers. That proposal, intended to attract overseas investment but seen by opponents as a crass and unnecessary break with history, was thrown out by the Football Association Council in April, casting Allam’s position into doubt. He had previously made the issue key to his ongoing involvement with Hull, and once said he would “walk away within 24 hours” if his rebrand was rejected. Yet with manager Steve Bruce manfully deflecting the off-field furore to lead the side to their first ever FA Cup final and the highest finish in their history, the matter went quiet. Fans continued with their Allam chants at matches, typically timed at 19:04 minutes to reflect the year the team was founded as Hull City AFC, but his public appearances and talk of departure largely stopped. Indeed, when Bruce plotted a radical overhaul of the playing staff this summer he found a sympathetic ear in the owner. The arrivals of Jake Livermore, Robert Snodgrass and Abel Hernandez all broke the club’s previous transfer record, with the latter becoming Hull’s first £10million player. If anything, Allam’s commitment appeared to be stronger than ever due to his financial backing of Bruce. Now there appears to be another chapter to the story, with Allam set to follow his announcement with a rare open session with reporters. If past experience is anything to go by it could be a fiery event, with the FA, Hull City Council and disgruntled elements of the club’s support all among his perceived enemies. Back on the field, there was encouragement from two of Bruce’s deadline day arrivals. A Hull XI drew 2-2 in a behind-closed-doors friendly against West Brom, with newcomers Hatem Ben Arfa and Gaston Ramirez, both on season long loans at the KC Stadium, on the scoresheet. Press Associationlast_img read more

Costa back in the goals as Chelsea give boss Mourinho much-needed win

first_img Costa ended a six-match barren spell, prompting chants of “we are staying up” and “Jose Mourinho”, as the Barclays Premier League champions secured a fourth win in their 13th Barclays Premier League game of the season to edge away from the foot of the table. Three years to the day since Rafael Benitez was installed as interim successor to Champions League-winning boss Roberto di Matteo, Mourinho was desperate to end a run of three straight league losses in front of the watching Roman Abramovich. Mourinho selected 19-year-old Brazilian teenager Kenedy at left-back and restored Fabregas to his starting line-up. The Blues’ attacking build-up play was improved, but they were defensively suspect and Nathan Redmond was denied by Begovic after Terry’s poor headed clearance. Fabregas had fired a Hazard cutback over by then and Willian was denied by Ruddy before Costa’s first gilt-edged chance. Referee Craig Pawson rejected three penalty appeals – two from Chelsea, one from Norwich – in the first half, with replays justifying the decisions. The match could have swung either way in the space of 60 seconds prior to half-time. Terry blocked a Bassong shot as Chelsea scrambled clear a corner, with Kenedy crossing and Costa’s effort deflecting wide off Ruddy’s right leg on the counter. Hazard was growing in confidence as Chelsea pressed in the second half, but few of his team-mates were on his wavelength and Costa appeared on a different frequency altogether. Another Hazard cross evaded everyone, with Costa absent. He was present when it mattered, though, bringing down Fabregas’ free-kick before cutting inside Ryan Bennett and shooting inside the far post. Zouma directed a Willian free-kick on to the bar soon afterwards and Nemanja Matic waltzed through only to be denied by Ruddy. Norwich had chances, too, with Brady’s shot saved by Begovic, but Chelsea held on to ease the pressure on Mourinho, who punched the air in relief when he heard the final whistle. TWEET OF THE MATCH Real relegation 6-pointer at Chelsea, or is that a bit harsh on Norwich? – Match of the Day presenter Gary Lineker (@GaryLineker) took a tongue-in-cheek view of the clash at Stamford Bridge Chelsea Asmir Begovic: 7 (out of 10) Branislav Ivanovic: 6 Kenedy: 6 Kurt Zouma: 7 John Terry: 6 Nemanja Matic: 6 Cesc Fabregas: 6 Pedro: 7 Willian: 7 Diego Costa: 6 Eden Hazard: 7 Substitutes: Oscar: 6 Ramires: 6 Cesar Azpilicueta: 6 Norwich John Ruddy: 8 Andre Wisdom: 7 Martin Olsson: 6 Ryan Bennett: 7 Sebastien Bassong: 7 Jonny Howson: 6 Youssouf Mulumbu: 7 Gary O’Neil: 7 Robbie Brady: 7 Nathan Redmond: 7 Dieumerci Mbokani: 6 Substitutes: Wes Hoolahan: 6 Graham Dorrans: 6 Cameron Jerome: 6 STAR PLAYER John Ruddy: The England goalkeeper saved well from Willian, Diego Costa and Nemanja Matic to frustrate Chelsea. An honourable mention goes to Eden Hazard, who showed glimpses of a return to form. MOMENT OF THE MATCH After spurning two chances he would have gobbled up last term, Costa struck when found by Cesc Fabregas. It was his first goal since mid-October and just his fourth of the season. VIEW FROM THE BENCH Jose Mourinho, who was back in the dugout after being banished from Stoke’s Britannia Stadium on November 7, selected 19-year-old Brazilian Kenedy at left-back, with Cesar Azpilicueta dropping to the bench, and restored Branislav Ivanovic and Fabregas to the starting line-up. Alex Neil also made three changes, with Nathan Redmond, Youssouf Mulumbu and Dieumerci Mbokani coming in following the win over Swansea. Wes Hoolahan was among those to drop out, but came off the bench. Both sets of substitutes made little impact. MOAN OF THE MATCH Another Chelsea game featured penalty appeals and whining from the technical areas directed towards the officials. Mourinho kept his counsel and replays showed referee Craig Pawson was right every time. WHO’S UP NEXT Maccabi Tel-Aviv v Chelsea, November 24 (Champions League) Norwich v Arsenal, November 29 (Premier League) Mourinho, banned from the stadium for the defeat at Stoke, was the subject of the first managerial vote of confidence in Abramovich’s 12-year ownership on October 5. The caveat of the board’s support was that results had to improve and Chelsea have now won three times in eight games since. Here, Costa converted Cesc Fabregas’ quick free-kick for just his fourth goal of the season and first since last month’s defeat of Aston Villa. Costa had earlier been conspicuous by his absence when Eden Hazard – some of his effervescence restored – twice crossed well, while he wasted two other chances, reminiscent of Fernando Torres. He blasted over Pedro’s cutback and then was denied by John Ruddy two minutes before the break. Kurt Zouma also hit the bar after Chelsea had gone 1-0 up. Norwich had opportunities, with John Terry blocking a Sebastien Bassong effort and Asmir Begovic saving well from Robbie Brady. And, as with many Chelsea matches this season, there were penalty controversies. Costa and Bassong grappled at one point and Willian went down under a Jonny Howson challenge before escaping a foul for bundling over Brady at the other end. Jose Mourinho was back in the dugout and Diego Costa returned to the score sheet as Chelsea claimed a much-needed 1-0 win over Norwich. Press Associationlast_img read more

Men’s basketball breakdown: Wisconsin handles North Dakota

first_imgIt was smooth sailing for the Wisconsin men’s basketball team Tuesday night at the Kohl Center, where UW defeated North Dakota 78-64.Wisconsin (2-1) never trailed and held a lead for all but 52 seconds throughout the game. At one point, that lead reached a 26-point margin.All five UW starters scored in double figures. Ethan Happ and Bronson Koenig led the way with 17 points apiece. Vitto Brown added 12 points, and Nigel Hayes and Zak Showalter added 11 and 10, respectively.Here’s a breakdown of the Badgers’ second-straight win:When you knew it was overNo offense to North Dakota, but this thing was done from the first couple of minutes. Wisconsin jumped out to a 7-0 lead and not even ice cold shooting during the first half could get North Dakota back into the game.Wisconsin player of the game: Ethan HappHapp’s first two outings for the Badgers saw him getting limited playing time because of foul trouble and not much offensive contribution. That changed Tuesday night when Happ stayed in the game by limiting his fouls (only one in the first half). By halftime, the redshirt freshman had 11 points and six rebounds. He finished with 17 points and seven rebounds, with seven boards coming on the offensive glass.North Dakota player of the game: Geno CrandallCrandall managed only three points in the first half, but turned up the heat from downtown in the second half. In the final 20 minutes, Crandall was 5-for-5 from three-point range and finished the game 6-for-6, making just as many threes as the entire Wisconsin team.Crandall finished with a game-high 19 points and added five rebounds in just 22 minutes of action.Play of the game: Happ goes behind-the-backWith 10:29 remaining in the first half, freshman Charlie Thomas got his hands on a loose ball. Happ came up with it from the floor and started cruising up the court, not dribbling out of control. When he approached the three-point line, Happ weaved the ball around his torso, faking out the North Dakota defender with a behind-the-back move that brought “oooohs” and “aaahhhss” from the Kohl Center crowd.Now with a clear path to the basket, Happ rose high above the rim and threw down a tomahawk jam to put the Badgers up 21-11.NotableWhen UW head coach Bo Ryan emptied the UW bench in the game’s final minutes, freshman Brevin Pritzl didn’t enter the game. That’s because after playing four minutes in Sunday’s win over Siena, Pritzl told the coaching staff the foot he broke in August wasn’t feeling well.North Dakota was the team Frank Kaminsky scored his school-record 43 points against just less than two years ago (Nov. 19, 2013).Nigel Hayes may not be scoring the ball very well right now (he was 1-for-8 from the field Tuesday), but he has 15 assists and no turnovers through the season’s first three games.QuotableZak Showalter on Andy Van Vliet having to sit out 2015-16:“It’s just a bummer. He’s going to have to take it, do the best he can to prepare for next year and get a lot better. He’s got a big frame so he’s going to put on some weight, but he’s just got to stay positive. I know it’s frustrating to hear, but he’ll do the best he can.”Men’s basketball: Van Vliet ruled ineligible for 2015-16 seasonFreshman forward Andy Van Vliet has officially been ruled ineligible for the 2015-16 season after the NCAA upheld their initial Read…Ethan Happ on scoring off putbacks:“I don’t see myself as a garbage bucket man. I see those types of guys in high school, but I’m going to do whatever I can to help the team win. I don’t care if I score two points or if I score 17 points. It really doesn’t matter to me what I contribute as long as our team wins.”Bo Ryan on Nigel Hayes’ turnover-to-assist ratio: “How could you not like that? They’d have to lock me up if I said I didn’t like that.”last_img read more

Codere sanctions Credit Suisse to lead its Mexican charge

first_img Mozzartbet sets sail in South America taking over Meridianbet Colombia July 22, 2020 Spanish business news source El Confidencial reports that the governance of Grupo Codere SA has sanctioned investment bank Credit Suisse to lead its corporate refinancing, as the Bolsa Madrid gambling group reviews its South American options.The Swiss multinational bank is reported to have been given a two-fold mandate by Codere governance, being ordered to raise capital for new expansion projects and further undertaking a review of loss-making assets/divisions.Credit Suisse will likely carry out an operational review of Codere’s position within Argentina, the firm’s biggest operational market which plunged 2018 results, due to the Argentine Peso collapse.  Furthermore, news of Credit Suisse appointment follows speculation in Spanish media that Codere governance will likely sanction a sale of the firm’s Italian bingo and arcade properties, as increased GGR taxes have made Italy an unworkable territory for the Spanish legacy gambling group.Advancing future options, Credit Suisse is reported to be raising ‘necessary financing’ for Codere to form a LATAM strategic partnership with US entertainment and leisure group Hard Rock International.Securing new capital, Codere governance seeks to entice Hard Rock into a Mexican strategic partnership in which it will operate gambling units within Hard Rock’s four luxury Mexican hotel properties of Cancun, Los Cabos, Cozumel and Lázaro Cárdenas.Rapid Mexican expansion remains top of Codere governance’s agenda, with Credit Suisse reported to be assessing a potential buyout of Mexican media group Televisa’s 17 ‘Play City’ gambling establishments. Following an executive team shake-up in 2018, Televisa, Mexico’s biggest multimedia group announced that it would offload its entire Play City gambling division – seeking a ‘quickfire $300 million sale’.Closer to home, corporate stakeholders will be monitoring next month’s Group AGM closely, as Codere governance seeks to end the firm’s ongoing dispute between US debt holders and the enterprise founding Martinez Sampedro family.Entering a crucial H2 2019 period, in which Codere leadership seeks to implement various group transformation initiatives, the Spanish firm seeks to end a bitter board-level dispute which may impact future financing and growth strategies. Codere secures €250m credit lifeline on aggressive interest rates  July 14, 2020 Submit Related Articles Codere merges Italian fruit machine units forming CODWIN July 3, 2020 Share Share StumbleUponlast_img read more

Madrid face Utd as Barca take on Milan in Champs League last 16

first_imgThe draw for the round of 16 of the Champions League took place in Nyon, Switzerland on Thursday, and some enticing ties await in the first knock-out stage.Primera Division champions Real Madrid have been paired with Manchester United as Cristiano Ronaldo returns to Old Trafford.Furthermore, 2011 winners Barcelona will have to deal with Italian giants AC Milan in what promises to be yet another mouthwatering tie.Last season’s finalists Bayern Munich take on Arsene Wenger’s Arsenal as they aim to make it to their third final in five years’ time.Serie A powerhouse Juventus will have to deal with Celtic in the first knock-out stage, while Schalke meet Turkish giants Galatasaray.Group winners will be away in the first legs on 12-13 and 19-20 February and at home in the return matches on 5-6 and 12-13 March. The draw for the quarter-finals will be held on March 15, and the tournament concludes at Wembley Stadium on May 25.Champions League round of 16 draw:Galatasaray v FC SchalkeCeltic v JuventusArsenal v Bayern Munich Shakthar Donetsk v Borussia DortmundAC Milan v BarcelonaReal Madrid v Manchester UnitedValencia v Paris Saint-GermainFC Porto v Malagalast_img read more

NFL playoff odds report: Full betting guide & trends for NFC divisional round games

first_imgOddsmakers see Seahawks, Vikings as live underdogsAfter going on the road and winning on wild-card weekend, the Seahawks and Vikings are getting plenty of respect from sportsbooks. Seattle was the most popular team we have seen in the first round of the playoffs in over a decade, as an estimated 78 percent of bettors backed the Seahawks. That public love led to the oddsmakers making Seattle the shortest underdog of the NFL’s divisional round games, per the NFL betting odds, yet that hasn’t turned people off the Seahawks, and they are the most popular pick this week.Minnesota was the biggest underdog of wild-card weekend. The Vikings were as much as 8.5-point underdogs against the Saints last week, but they closed at +7 after a bevy of sharp money came in on Minnesota last Sunday. Their impressive win over the Saints in the Crescent City has some pundits believing they can beat the No. 1 overall seed in the NFC, so they are currently getting just seven points on the road against San Francisco. Betting trendsSeattle is the most popular play this week, and the Seahawks have continually paid off for bettors in recent years. They are 34-16-3 ATS in their last 53 games as an underdog per the football betting odds, and they are 8-1 ATS in their last nine games as a road underdog. However, Seattle has failed to cover the spread in any of its last six trips to Lambeau Field.As for the Packers, this team has continually risen to the occasion with a 7-1 ATS mark in its last eight games against teams with winning records. The one time they failed to cover was on the road against San Francisco back in late November, but Green Bay easily covered the number on the road against Kansas City and Minnesota, winning outright in both games. MORE: Get the latest NFL odds & betting trends from Sports InsiderSan Francisco 49ers (-7) vs. Minnesota Vikings, O/U 44This line has hovered around seven points since opening on Sunday night. We’ve seen the spread drop to 49ers -6.5 and rise to Vikings +7.5, so sportsbooks are hoping that the line doesn’t land right on seven. That would lead to a bloodbath since seven is such a key number. We have seen consistent action on the under. The total for this game opened at 45, and it has dropped to 44 without any buyback along the way. That’s a little curious if you’re a trend bettor as both San Francisco and Minnesota have seen most of their games go over the total this season.Betting trendsMinnesota’s victory over New Orleans last week was a surprise for more than a few reasons. The Vikings have not fared well against good teams in recent history, posting a 5-14 ATS record in their last 19 games against teams with a winning record. That doesn’t seem to bode well for them, but San Francisco has an even worse track record as a home favorite. The 49ers are 6-19-1 ATS in their last 26 games as a home favorite.  This game has the lowest total of any of the four Divisional Round games, and recent history indicates the under might be a good play too. The under is 6-1 in the last seven meetings between these two teams, and the under has cashed in 12 of Minnesota’s last 17 games against NFC opponents.Green Bay Packers (-4) vs. Seattle Seahawks, O/U 47We haven’t seen any movement on the spread in this game as it has remained solid at Green Bay -4 since it opened on Sunday night. Both Green Bay and Seattle are a little bit overhyped considering their advanced metrics, and both teams would be underdogs of at least four points per the NFL betting odds against San Francisco in the NFC Championship Game. There has been movement on the total though. Although it will be cold in Lambeau Field on Sunday afternoon, the elements aren’t expected to interfere with this game, helping the total rise from 46 to 47 early in the week.   last_img read more